Human Hapten-specific Lymphocytes: Biomarkers of Allergy in Man
نویسندگان
چکیده
Environmental pollutants and other chemicals may have increasing impact on the immune system of human beings. Disregulation of the immune system by chemicals may be one of the reasons why the frequency of allergies and autoimmune diseases increases. Human hapten-specific memory lymphocytes can be detected in the blood of patients with druginduced immunologic side effects but not in similarly exposed healthy individuals. The immune reactivity of human lymphocytes in vitro to white coloring agent—titanium dioxide (TiO2), and mercurial conservatives thimerosal and phenylmercury—has been studied. It was found that out of 650 patients tested, 3% reacted to titanium dioxide. The percentages for phenylmercury and thimerosal were 14% and 7%, respectively. Human memory cells can be used as markers of susceptibility in future choices of appropriate additives in pharmaceutic products.
منابع مشابه
Renaissance for hapten-specific T lymphocytes: implications for basic and applied research.
Protein-reactive chemicals and drugs (haptens), such as dinitro- (DNP) or trinitro-phenylated (TNP) reagents or penicillins, are potent inducers of allergic reactions in experimental animal systems as well as in humans. Hapten-specific T lymphocytes are mediators of these disorders. Like other antigens, hapten determinants on target cells are recognized by the T cell's antigen-specific receptor...
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Protein-reactive chemicals and drugs (haptens), such as dinitro(D N P) or trinitro-phenylated (TNP) reagents or penicillins, are potent inducers o f allergic reactions in experimental ani mal systems as well as in humans. Hapten-specific T lymphocytes are mediators o f these disor ders. Like other antigens, hapten determinants on target cells are recognized by the T cell’s antigen-specific re...
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